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The Kansas Jayhawks have their sights set on taking home the fourth national title in program history in the 2022 NCAA Tournament. Led by Big 12 Conference Player of the Year Ochai Agbaji, the Jayhawks won the Big 12 Tournament and earned the No. 1 seed in the Midwest Region of the March Madness bracket 2022. The Jayhawks' first-round opponent is No. 16 seed Texas Southern, who earned its spot in the NCAA Tournament by winning the SWAC Tournament and then defeating Texas A&M-CC in a First Four matchup on Tuesday night.

Tipoff from Dickie's Arena in Fort Worth, Tex. is set for 9:57 p.m. ET on Thursday, Mar. 17. The Jayhawks are favored by 21.5 points in the latest Texas Southern vs. Kansas odds at Caesars Sportsbook, while the over-under for total points scored is 145.5. Before making any Kansas vs. Texas Southern picks, you need to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Kansas vs. Texas Southern, and just locked in its picks and March Madness predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Texas Southern vs. Kansas:

  • Kansas vs. Texas Southern spread: Jayhawks -21.5
  • Kansas vs. Texas Southern over-under: 145.5 points 
  • Kansas vs. Texas Southern money line: Tigers +2500, Jayhawks -15000
  • KAN: Kansas is 17-16-1 against the spread in road or neutral site games
  • TS: Texas Southern is 4-0 against teams allowing 67-72 points per game

Why Kansas can cover

The Jayhawks enter the 2022 NCAA Tournament on tear, winning their three Big 12 Conference Tournament games by an average margin of victory of 15.3 points per game. Bill Self's squad is led by Agbaji, who averages 19.7 points, 5.1 rebounds, and 1.6 assists per game. 

Kansas is an elite offensive team, ranking 25th in the country in points scored per game (78.6), 18th in field goal percentage (48.1%), and 81st in 3-point field-goal percentage (35.5%). The Jayhawks have four starters averaging double-digit points per game -- Agbaji, Christian Braun (14.6), Jalen Wilson (10.9), and David McCormack (10.1). Kansas is 17-17 against the spread in 2021-22.

Why Texas Southern can cover

Texas Southern won the SWAC Tournament and punched its ticket to the Big Dance for the second consecutive season despite having no players earn first or second-team All-Conference honors. A big reason for their success is veteran leadership. KenPom ranks the Tigers as the third-most experienced team in the NCAA Tournament field.

Texas Southern will have its hands full trying to contain Kansas' uptempo offensive attack, but the Tigers have been playing well on the defensive end as of late, allowing 55.3 points per game over their last three contests. Texas Southern is allowing 65.5 points per game on the season, while scoring an average of 69.5 points per game. The Tigers are 17-13-1 against the spread in 2021-22.

How to make Kansas vs. Texas Southern picks

SportsLine's model is leaning under on the total, projecting a combined 144 points. It also says one side of the spread hits almost 60 percent of the time. You can only get the model's Texas Southern vs. Kansas pick at SportsLine.

So who wins Kansas vs. Texas Southern? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to see which side of the Texas Southern vs. Kansas spread to jump on, all from the advanced model that is up almost $1,500 on its top-rated college basketball spread picks over the last five-plus years, and find out.