COLLEGE BASKETBALL: NOV 18 Villanova at Michigan State
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The No. 20 Michigan State Spartans will try to build on their two-game winning streak when they face the Notre Dame Fighting Irish on Wednesday night in the 2022 ACC/Big Ten Challenge. Michigan State snuck past Portland in a 78-77 final on Sunday after beating Oregon on Saturday. Notre Dame had its perfect start to the season come to an end in a 63-51 loss to St. Bonaventure on Friday. 

Tipoff is set for 9:15 p.m. ET. The Spartans are favored by 2 points in the latest Notre Dame vs. Michigan State odds from Caesars Sportsbook, while the over/under is set at 139.5. Before entering any Michigan State vs. Notre Dame picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,500 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Notre Dame vs. Michigan State. You can head to SportsLine to see its picks. Here are several college basketball odds for Michigan State vs. Notre Dame:

  • Notre Dame vs. Michigan State spread: Notre Dame +2
  • Notre Dame vs. Michigan State over/under: 139.5 points
  • Notre Dame vs. Michigan State money line: Notre Dame +110, Michigan State -125
  • Notre Dame vs. Michigan State picks: See picks here
Featured Game | Notre Dame Fighting Irish vs. Michigan State Spartans

Why Notre Dame can cover

Notre Dame will be happy to return home on Wednesday following its loss to St. Bonaventure on Friday. The Fighting Irish had won their first five games of the season and have now won 10 consecutive home games. Senior forward Nate Laszewski is averaging 18.2 points per game, leading five players who are averaging double figures in scoring. 

Senior guard Dane Goodwin (14.3), freshman JJ Starling (12.8), senior Trey Wertz (11.8) and senior Cormac Ryan (10) are also in double digits. Niagara transfer Marcus Hammond missed the first six games with a sprained MCL, but he might be able to play on Wednesday. Meanwhile, Michigan State is without senior forward Malik Hall, who is one of the top players on the team. 

Why Michigan State can cover

Michigan State might have two losses this season, but both of those setbacks came against ranked opponents in Gonzaga and Alabama. The Spartans bounced back from the loss to the Crimson Tide with consecutive wins over Oregon and Portland last weekend. They were without Hall and sophomore guard Jaden Akins during those games, but Akins could return on Wednesday. 

Senior guard Tyson Walker and senior forward Joey Hauser are combining for nearly 30 points per game, so they should be able to overcome Hall's absence. Notre Dame is coming off a rough showing against St. Bonaventure, as it was a 6-point favorite in that 12-point loss. The Fighting Irish have failed to cover the spread in six straight games, and they have only picked up one win in their last eight games against Big Ten opponents.

How to make Michigan State vs. Notre Dame picks

The model has simulated Notre Dame vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Michigan State vs. Notre Dame? And which side of the spread hits 60% of the time? Visit SportsLine to see which side of the Notre Dame vs. Michigan State spread to jump on, all from the advanced model that is up over $1,500 on its college basketball picks the last six years, and find out.