The Siena Saints (3-2) and the Ole Miss Rebels (5-0) square off in the semifinals of the 2022 ESPN Events Invitational on Friday morning. The Saints come into the game riding high after upsetting Florida State 80-63 in the opening round. On the other side, Ole Miss outlasted Stanford 72-68 in its first game on Thursday.

Tip-off from the State Farm Field House in Lake Buena Vista, Fla., is set for 11 a.m. ET. The Rebels are 12-point favorites in the latest Ole Miss vs. Siena odds at Caesars Sportsbook. The over/under for total points is set at 133.5. Before making any Siena vs. Ole Miss picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,400 for $100 players on its top-rated college basketball picks against the spread. 

Now, the model has set its sights on Ole Miss vs. Siena and just locked in its picks and CBB predictions. You can see the pick sat SportsLine. Here are the college basketball odds and betting lines for Siena vs. Ole Miss:

  • Ole Miss vs. Siena spread: Ole Miss -12
  • Ole Miss vs. Siena over/under: 133.5
  • Ole Miss vs. Siena money line: Ole Miss -800, Siena +550
  • Ole Miss vs. Siena picks: See picks at SportsLine
Featured Game | Ole Miss Rebels vs. Siena Saints

Why Siena can cover 

Siena rolls into this game on a high note. The Saints upset Florida State 80-63 in the first round of the 2022 ESPN Events Invitational. The Saints played stifling defense, forcing the Seminoles to shoot just 36% from the field and 26% from downtown. Meanwhile, they had it clicking on the offensive end. The Saints shot 52% from the field and had three players in double figures.

Senior guard Andrew Platek led the way for this group, dropping 20 points in the win. Platek was able to catch fire from deep, knocking down five 3-pointers. The New York native was creating space from defenders and thrived in catch-and-shoot situations. Sophomore guard Javian McCollum also played well in the backcourt. McCollum set his teammates up, logging a career-high eight assists with 18 points.

Why Ole Miss can cover

Junior guard Matthew Murrell is the go-to option on the offensive end for the Rebels. Murrell is one of the best 3-point shooters on the floor and owns a quick trigger. The Tennessee native can put the ball on the deck and attack the lane to keep the defense honest. Murrell averages a team-high 15.4 points with 4.2 rebounds and 3.4 assists per game. On Nov. 15, he logged 25 points and five boards.

Senior forward Robert Allen is a long and athletic player in the frontcourt. Allen crashes the glass hard and creates extra opportunities for his team. The Florida native is active on cuts and is constantly charging the paint. He puts up 7.4 points and 5.2 rebounds per game. On Nov. 11, Allen amassed 10 points and four rebounds. 

How to make Ole Miss vs. Siena picks

SportsLine's model is leaning Over on the total, projecting 140 combined points. The model also says one side of the spread has all the value. You can see the picks here.

So who wins Siena vs. Ole Miss? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.