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The Brigham Young Cougars (2-0) and the No. 12 Oregon Ducks (2-0) are set to square off in the Phil Knight Invitational at 10 p.m. ET on Tuesday, November 16 at Moda Center at the Rose Quarter in Portland, Ore. The Ducks are coming off an impressive 86-63 home win over SMU, a NCAA Tournament team last year, last Friday. BYU also notched a 66-60 win over San Diego State on Friday. Both teams are 1-1 against the spread in 2021.

Oregon is favored by 4.5 points in the latest Oregon vs. Brigham Young odds from Caesars Sportsbook, and the over-under is set at 141.5. Before making any Oregon vs. BYU picks, you need to see the college basketball predictions and betting advice from the red-hot simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has locked in on Oregon vs. Brigham Young and just revealed its picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for Oregon vs. Brigham Young:

  • Oregon vs. BYU spread: Oregon -4.5
  • Oregon vs. BYU over-under: 142 points
  • Oregon vs. BYU moneyline: Oregon -190, BYU +160
Featured Game | Oregon Ducks vs. Brigham Young Cougars

What you need to know about Oregon

Oregon was dominant in its game against the SMU Mustangs this past Friday, notching an impressive 86-63 victory. Four players on Oregon scored in the double digits: forward Eric Williams Jr. (19), guard Will Richardson (18), guard Jacob Young (18), and guard Rivaldo Soares (10).

Head coach Dana Altman has a solid seven-man rotation, but can go deeper if needed. This year's Oregon team is smaller than in years past, and will often times trot out an entire starting five that stands 6-foot-8 or shorter. The Ducks are looking like one of the better offensive teams in the country, and will be lethal if their three-point shots are falling. 

What you need to know about Brigham Young

Meanwhile, BYU didn't have too much breathing room in their contest with the San Diego State Aztecs this past Friday, but they still walked away with a 66-60 win. The top scorer for BYU was guard Alex Barcello (17 points).

The Cougars are led by Barcello, an Arizona transfer, and sophomore Caleb Lohner, a scrappy and athletic sophomore forward. Head coach Mark Pope has developed BYU into one of the best mid-major programs in the country, but the Cougars will need to knock down shots from beyond the arc to cover and potentially win this intriguing early season CBB matchup.

How to make Oregon vs. BYU picks

The model has simulated Oregon vs. Brigham Young 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model's BYU vs. Oregon pick at SportsLine.

So who wins BYU vs. Oregon? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the Oregon vs. BYU spread to jump on, all from the advanced model that is up $2,100 on its college basketball picks the last five years, and find out.