Chattanooga led 21-3 in the first quarter for its most points in the opening frame since 2017.
Tyrell Price, Gino Appleberry and Ailym Ford each rushed for 70-plus yards and a score for Chattanooga (2-2, 1-0 Southern). Price's TD went for 57 yards and Ford had a 54-yarder as six rushers combined for 271 yards while WCU was held to 277 total yards.
Ford, who entered with back-to-back 100-yard rushing games, carried it 16 times for 74 yards to become the fastest high-school signee to reach 1,500 career yards rushing in program history.
Both of KeShawn Toney's catches went for a touchdown, and Telly Plummer, Brandon Dowdell and Jerrell Lawson each made an interception for Chattanooga.
Western Carolina (0-5, 0-2) is still seeking its first victory under first-year head coach Kerwin Bell. The Catamounts had their road losing streak extended to 11 games.
WCU has dropped 11 of the last 12 series meetings - and 15 of the last 18 overall dating to 2006.
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