After Kaleb Mosley kicked 46- and 42-yard field goals and Deveon Bryant turned a fumble recovery into a two-play, 5-yard drive with a 1-yard TD run, Ellis took over.
Ellis found Karate Brenson for a 12-yard score and Devon Starling for a 49-yard touchdown for a 27-0 lead for the Tigers (3-4, 2-0 Ohio Valley Conference) with 31 seconds to go in the half.
Jonah O'Brien got the Panthers (2-5, 1-1) back in the game with a pair of touchdown passes in the third quarter but Mosley connected with another 42-yard kick and then Ellis found John Roberts IV for a 52-yard score.
Ellis was 27 of 36 for 309 yards.
Two Eastern Illinois quarterbacks combined to go 10 of 29 and three interceptions.
More AP college football: https://apnews.com/hub/college-football and https://twitter.com/AP-Top25. Sign up for the AP's college football newsletter: https://apnews.com/cfbtop25
Copyright 2023 STATS LLC and Associated Press. Any commercial use or distribution without the express written consent of STATS LLC and Associated Press is strictly prohibited.