Hiers completed 24 of 30 passes with an interception for Samford (3-1) in a Southern Conference opener.
Hiers opened the scoring with a 20-yard touchdown pass to Judd Cockett midway through the first quarter. He upped the Bulldogs' lead to 14-0 with a 34-yard strike to Chandler Smith early in the second quarter.
Hiers connected with Jaylan Thomas for a 60-yard score and a 21-6 lead in the third quarter. Hiers and Ty King teamed up for a 15-yard touchdown in the fourth. Jay Stanton added a 49-yard touchdown run with 9:47 left to play. Smith finished with eight catches for 125 yards.
Richard McCollum kicked four field goals for Western Carolina (2-2).
Carlos Davis completed 29 of 44 passes for 301 yards for the Catamounts, but he was picked off twice.
Samford leads the all-time series 17-3. The Catamounts haven't won in Birmingham since 1969.
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