Scott, a Nicholls State transfer, was 17 of 25 passing for 391 yards. He connected with nine receivers that included six completions of 36 yards or more. Taylor Grimes caught two touchdown passes and finished with 126 yards receiving. Darion Chafin added four receptions for 106 yards and a score.
The Cardinals scored three touchdowns plus added a safety in the first quarter. Scott threw a 66-yard touchdown pass and a 55-yarder each to Grimes. Scott's scoring run came from 6 yards out.
Scott's 79-yard touchdown pass to Chafin made it 29-7 early in second quarter. Tiji Paul had a pick-six for the Cardinals in the third.
Romeir Elliott had 103 yards rushing and a touchdown for Southern Illinois.
The start was delayed 40 minutes due to weather.
More AP college football: https://apnews.com/hub/college-football and https://twitter.com/ap-top25. Sign up for the AP's college football newsletter: https://bit.ly/3pqZVaF
Copyright 2023 STATS LLC and Associated Press. Any commercial use or distribution without the express written consent of STATS LLC and Associated Press is strictly prohibited.