Scott, a graduate transfer from Nicholls, had a pair of 7-yard touchdown runs in the first quarter to stake Incarnate Word to a 14-0 lead, and after McNeese answered with 10 second-quarter points, hit Taylor Grimes from 11 yards out for a 21-10 halftime lead.
Scott hit Grimes with two more touchdown passes in the second half, including a 33-yard strike in the third quarter, and tossed 23 yards to CJ Hardy.
Scott was 25 of 35 for 347 yards and added 49 yards rushing on 10 carries as the Cardinals (4-1, 1-1) amassed 550 yards offense. Marcus Cooper added 25 carries for 135 yards and Grimes caught eight passes for 115 yards.
McNeese (1-4, 0-1) managed 310 yards of offense. Knox Kadum was 13-of-26 passing for 144 yards. Deonta McMahon carried 17 times for 88 yards.
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