The Memorial Day MLB schedule features several teams making long overnight trips to start new series on the West Coast as part of the 11-game slate. The Los Angeles Dodgers head home after a fierce three-game battle with the Tampa Bay Rays and host the Washington Nationals on Monday at 9:10 p.m. ET. The New York Yankees also head west to face the Seattle Mariners in a cross-division matchup of AL playoff teams from last season. Mike Soroka will make his first start in almost three years for the Atlanta Braves, who are in Oakland to face the Athletics. Soroka, who went 13-4 with a 2.68 ERA as a rookie in 2019, tore his Achilles' tendon twice and hasn't pitched in MLB since Aug. 3, 2020.

Atlanta is one of the best teams in the NL, while the A's have the worst record in baseball. First pitch for Braves vs. Athletics is set for 8:07 p.m. ET, and Atlanta is a -260 favorite (risk $260 to win $100) in the MLB odds at Caesars Sportsbook. Oakland is a +210 underdog, and the over/under for total runs scored is 9. The Memorial Day MLB schedule offers plenty of wagering options among the 11 matchups, and you can cash in huge if you combine your favorite picks into an MLB parlay. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 29-20 roll on all-top rated MLB picks (+319). Anybody who has followed it has seen profitable returns. 

Now, the model has locked in three confident MLB best bets for Memorial Day -- all involve games starting after 5:05 p.m. ET. If you successfully parlay the picks, you'd be looking at a payout of almost 4-1. You can only see the model's MLB picks for Memorial Day at SportsLine

Top MLB picks today

One pick the model loves as part of the parlay is the Dodgers -1.5 on the run line (-125) against the Nationals. Washington is in last place in the NL East, while the Dodgers are first in the West. Los Angeles has a lot more firepower in its lineup, and it appears to have the edge in the pitching matchup. Max Muncy, who hit his 17th home run (T-2 in MLB) in an 11-10 loss to Tampa Bay on Sunday, could sit with a hamstring issue, but there are plenty of other big bats in the lineup. The Dodgers have hit seven home runs in their past two games.

Los Angeles is tied for second in the majors with 89 home runs, while the Nationals have the second-fewest with just 39. Freddie Freeman, Mookie Betts and J.D. Martinez have combined for 30 homers and 96 RBI this season. The Dodgers have scored 298 runs (5.5 per game), compared to 226 (4.3) for the Nationals. L.A. starter Bobby Miller made his MLB debut against the Braves last week and allowed four hits and one run in an 8-1 victory. Trevor Williams, who has allowed 12 runs and five homers over his past four starts, is expected to start for the Nats. See who else to back here.

Featured Game | Los Angeles Dodgers vs. Washington Nationals

How to make MLB parlays for Memorial Day

The model has locked in two other best bets for Monday, including a confident run-line play that hits well over 70% of the time. You can only see the model's MLB parlay picks and best bets for Monday at SportsLine

Which MLB picks should you target for Monday in a parlay offering a payout of almost 4-1? Visit SportsLine now to see the MLB best bets for Monday from the model that is 331-285 on top-rated MLB money-line picks the past two seasons, and find out.