The San Francisco Giants visit the Colorado Rockies on Tuesday to kick off a three-game series between middling NL West rivals that are both hungry for a momentum-building performance. First pitch is scheduled for 8:40 p.m. ET from Coors Field. The Giants (29-30) are coming off a six-game homestand in which they won just one game each against the Pittsburgh Pirates and Baltimore Orioles. They enter Tuesday 5.5 games behind the Arizona Diamondbacks in the NL West standings. The Rockies (26-35) return from a 2-6 road trip that included a four-game sweep at the hands of Arizona before winning two of three from the Kansas City Royals. They currently sit 9.5 games out of first place. 

The Giants are -140 betting favorites (risk $140 to win $100), while the Rockies are offered at +118 in the latest MLB odds from Caesars Sportsbook MLB odds. The over/under for total runs scored is 11. The game is one of 15 on the MLB schedule for Tuesday. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer simulation model

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 32-24 roll on all-top rated MLB picks (+379). Anybody who has followed it has seen profitable returns.

For Tuesday, the model has locked in three confident MLB best bets for games that begin at 7:40 p.m. ET or later. If you successfully parlay the picks, you'd be looking at a payout of nearly 7-1. You can only see the model's MLB picks at SportsLine.

Top MLB picks today

After simulating every game on Tuesday 10,000 times, the model is picking the Los Angeles Angels (-125) to defeat the Chicago Cubs (+105). The model sees the Angels winning this matchup (9:40 p.m. ET) at least 57% of the time. Los Angeles is coming off a 3-4 road trip but avoided a four-game sweep at the hands of the Houston Astros with a 2-1 victory Sunday. The Cubs split a four-game series with the San Diego Padres but lost the finale 5-0 on Monday night. 

The Angels could see a boost to their lineup as high-priced third baseman Anthony Rendon is expected to return after missing more than three weeks because of a strained groin. Left-hander Tyler Anderson (2-1, 5.47 ERA) will start for Los Angeles on Tuesday. He is 4-3 with a 3.90 ERA in nine career starts against the Cubs. Chicago right-hander Hayden Wesneski (2-2, 4.81) has a 4.64 ERA in four road starts this season. See who else to back here.

Featured Game | Los Angeles Angels vs. Chicago Cubs

How to make MLB parlays for Tuesday, June 6

The model also locked in two other best bets for Tuesday, including a play on an underdog that would return plus-money. You can only see the model's MLB parlay picks and best bets at SportsLine

What MLB picks should you target for a payout of nearly 7-1, and what underdog does the model like on Tuesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 32-24 run on top-rated money-line picks, and find out.