Lambeau Field will showcase a Week 4 matchup between prominent rivals on Thursday Night Football. The Green Bay Packers will welcome the Detroit Lions to town and the matchup opens a 16-game slate across the league this week. Green Bay came back from a 17-point deficit to defeat the New Orleans Saints in Week 3, improving to 2-1 this season. Detroit is also 2-1, including a 1-0 mark on the road, and took care of business in a 20-6 win over the Atlanta Falcons last week. 

Kickoff is set for 8:15 p.m. ET on Thursday at Lambeau Field. The latest Lions vs. Packers odds list Detroit as a two-point favorite and the over/under for total points scored at 45. Before you make any Packers vs. Lions picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2023 NFL season on an incredible 167-117 run on top-rated NFL picks that dates back to the 2017 season. It also is on an 21-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Lions vs. Packers 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Packers vs. Lions:

  • Lions vs. Packers spread: Detroit -2
  • Lions vs. Packers Over/Under: 45 points
  • Lions vs. Packers money line: Detroit -130, Green Bay +110
  • DET: Lions are 10-2 ATS in their past 12 NFC North matchups
  • GB: Packers are 11-2 ATS as underdogs since the 2021 season
  • Lions vs. Packers picks: See picks at SportsLine

Why the Lions can cover

Detroit's defense is operating at an above-average level, headlined by a top-eight mark in yards allowed per play (4.6) this season. The Lions are still led by a dynamic offense, however, and that group has keyed Detroit to 10 wins in the last 13 games. Jared Goff ranks firmly in the top 10 in several passing categories, including passing touchdowns, passer rating, completion rate, and passing yards.

Goff's strong play is aided by the presence of Amon-Ra St. Brown, who is one of the best wide receivers in the game today. St. Brown caught nine passes for 102 yards in Week 3, marking his second straight 100-yard game. He is in the top 10 of the NFL in receptions (21) and yards (275) so far this season. He ranks in the top eight with 12.7 yards per touch and was No. 7 in the NFL with 106 catches last season. The partnership between Goff and St. Brown has been fruitful for Detroit's overall offense, as the Lions have scored 20 or more points in 12 straight games, the longest streak in the NFL. See who to back at SportsLine

Why the Packers can cover

Green Bay will aim for revenge after losing three straight games to Detroit, and the Packers bring the better defense into TNF. Detroit has struggled in a few key areas in three games on offense, including only 3.6 yards per carry, and the Lions are below-average in both third down efficiency (37.5%) and red zone efficiency (55.6%). Green Bay pass-rusher Rashan Gary is a devastating threat, as evidenced by three sacks in Week 3. Gary is a former first round pick from Michigan and ranks in the top eight of the NFL in sacks so far this season.

The Packers are giving up fewer than five yards per play in 2023, including 4.2 against Atlanta in Week 3. Green Bay also ranks in the top 10 in both red zone efficiency allowed (44.4%) and third down efficiency allowed (31.0%) to opponents. That helps the Packers to allow fewer than 21 points per game. See who to back at SportsLine.

How to make Lions vs. Packers picks

SportsLine's model is leaning Under the total, projecting 43 combined points. The model also says one side of the spread hits in nearly 60% of simulations. You can only see the model's NFL picks and analysis at SportsLine

So who wins Packers vs. Lions on Thursday Night Football, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Packers vs. Lions spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.