The San Francisco 49ers will try to continue a historic streak when they take the field on Thursday Night Football. Kyle Shanahan and the 49ers have won 12 consecutive regular season games, and the 49ers will host the New York Giants in Week 3. This tilt is also the home opener for the 49ers after back-to-back road wins. New York is 1-1 this season, with a blowout loss to Dallas in the opener and a comeback win over Arizona in Week 2. 

Kickoff is at 8:15 p.m. ET. San Francisco is a 10.5-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest 49ers vs. Giants odds. Before making any Giants vs. 49ers picks or NFL predictions, be sure to see what SportsLine's resident Niners expert, Micah Roberts, has to say, considering his mastery of picks involving San Francisco

Roberts has worked in the Las Vegas sportsbook industry for more than 20 years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He's also uniquely dialed into the San Francisco 49ers, with a 17-5 run on his against-the-spread NFL picks involving the Niners that has returned $1,150 to bettors. Anyone who has followed him is way up.

Now, Roberts has zeroed in on Niners vs. Giants and just locked in his picks and TNF predictions. You can head to SportsLine to see his picks. Now, here are several NFL odds and betting lines for Giants vs. Niners:

  • 49ers vs. Giants spread: 49ers -10.5
  • 49ers vs. Giants over/under: 44 points
  • 49ers vs. Giants money line: 49ers -550, Giants +410
  • NYG: Giants are 14-7 against the spread in the last 21 games
  • SF: 49ers are 14-8 against the spread in the last 22 games
  • 49ers vs. Giants picks: See picks at SportsLine

Why the Giants can cover

New York's defense showed tangible improvement in the second half of Week 2, helping to boost the team to a comeback win. The Giants are in the top 10 of the NFL in passing defense through two weeks, yielding only 187.5 yards per game, and opponents have only one passing touchdown against New York. The Giants have given up only 322.0 total yards per game, and that builds off a strong 2022 performance in key metrics. New York was in the top five in third down efficiency allowed (35.1%) and red zone efficiency allowed (49.2%) last season and allowed only 6.9 yards per attempt with 41 sacks last year.

On offense, New York erupted for 358 total yards and 8.7 yards per play in the second half against the Cardinals last week and is converting nearly 43% of third down chances through two weeks. Led by quarterback Daniel Jones, the Giants put together a highly efficient attack that was able to avoid mistakes a year ago, and Jones was able to provide a dual-threat element that helped the Giants post top-five marks in rushing yards, yards per carry, and rushing touchdowns in 2022. See which team to pick here.

Why the 49ers can cover

The 49ers appear to be thoroughly dominant on both sides of the ball this season, and San Francisco also has the benefit of home-field advantage on a short week. San Francisco leads the NFL in rushing touchdowns (four) and yards per carry (5.6) so far this season, and the 49ers are in the top five in rushing yards (347), points per game (30.0), and scoring percentage (54.5% of possessions).

The 49ers are generating 378.0 total yards of offense per game, and San Francisco already has 43 first downs in two weeks. In contrast, New York's defense has yielded 68 points in two games, and the 49ers clearly project to be better on the defensive side. San Francisco is giving up only 15.0 points per game and 1.43 points per possession this season, with opponents scoring on fewer than 30% of drives against the 49ers. San Francisco also has six sacks, ten tackles for loss, and four takeaways in two games, and the 49ers are stout against the run, giving up only 65.0 yards per contest. See which team to pick here.

How to make 49ers vs. Giants picks

Roberts is leaning Over on the point total, but he also has isolated a critical X-factor that has him going big on one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Giants vs. 49ers on Thursday Night Football, and which critical X-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Giants vs. 49ers spread to back, all from the expert who is an impressive 17-5 on spread picks involving San Francisco, and find out.