Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | T. LawrenceTrevor Lawrence | C. BeathardC.J. Beathard | — |
| Running Back | T. EtienneTravis Etienne | T. BigsbyTank Bigsby | |
| Wide Receiver | C. RidleyCalvin Ridley | C. KirkChristian Kirk | |
| Tight End | E. EngramEvan Engram | L. FarrellLuke Farrell | |
| Left Tackle | W. LittleWalker Little | — | — |
| Left Guard | B. BartchBen Bartch | B. HanceBlake Hance | — |
| Center | L. FortnerLuke Fortner | T. ShatleyTyler Shatley | — |
| Right Guard | B. ScherffBrandon Scherff | — | — |
| Right Tackle | A. HarrisonAnton Harrison | C. Van LanenCole Van Lanen | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | A. GotsisAdam Gotsis | T. LacyTyler Lacy | |
| Nose Tackle | F. FatukasiFoley Fatukasi | J. LedbetterJeremiah Ledbetter | |
| Right Defensive End | R. Robertson-HarrisRoy Robertson-Harris | A. BlacksonAngelo Blackson | — |
| Left Inside Linebacker | D. LloydDevin Lloyd | C. MumaChad Muma | |
| Right Inside Linebacker | F. OluokunFoye Oluokun | S. QuartermanShaquille Quarterman | |
| Strongside Linebacker | T. WalkerTravon Walker | K. ChaissonK'Lavon Chaisson | — |
| Weakside Linebacker | J. AllenJosh Allen | S. QuartermanShaquille Quarterman | |
| Right Cornerback | D. WilliamsDarious Williams | M. BrownMontaric Brown | |
| Left Cornerback | T. CampbellTyson Campbell | T. HerndonTre Herndon | |
| Strong Safety | R. JenkinsRayshawn Jenkins | A. WingardAndrew Wingard | |
| Free Safety | A. CiscoAndre Cisco | D. ThomasDaniel Thomas | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | L. CookeLogan Cooke | — | — |
| Kicker | B. McManusBrandon McManus | — | — |
| Long Snapper | R. MatiscikRoss Matiscik | — | — |
| Holder | L. CookeLogan Cooke | — | — |
| Punt Returner | J. AgnewJamal Agnew | P. WashingtonParker Washington | — |
| Kick Returner | J. AgnewJamal Agnew | P. WashingtonParker Washington | — |