Buffalo Bills
| Team Ranking | Overall | Rushing | Passing |
| Offense | 24th | 128.4 (8th) | 201.8 (26th) |
| Defense | 3rd | 103.1 (10th) | 195.2 (4th) |
Schedule
* Sat Aug 13 4:00 pm ET | NFLN | IND |
* Sat Aug 20 1:00 pm ET | NFLN | DEN |
* Fri Aug 26 7:00 pm ET | @CAR | |
| Thu Sep 8 8:20 pm ET | NBC | @LAR |
| Mon Sep 19 7:15 pm ET | ESPN | TEN |
| Sun Sep 25 1:00 pm ET | CBS | @MIA |
| Sun Oct 2 1:00 pm ET | CBS | @BAL |
| Sun Oct 9 1:00 pm ET | CBS | PIT |
| Sun Oct 16 4:25 pm ET | CBS | @KC |
| Sun Oct 30 8:20 pm ET | NBC | GB |
| Sun Nov 6 1:00 pm ET | CBS | @NYJ |
| Sun Nov 13 1:00 pm ET | FOX | MIN |
| Sun Nov 20 1:00 pm ET | CBS | CLE |
| Thu Nov 24 12:30 pm ET | CBS | @DET |
| Thu Dec 1 8:15 pm ET | AMZN | @NE |
| Sun Dec 11 1:00 pm ET | CBS | NYJ |
| Sun Dec 18 TBA | MIA | |
| Sat Dec 24 1:00 pm ET | CBS | @CHI |
| Mon Jan 2 8:30 pm ET | ESPN | @CIN |
| Sun Jan 8 TBA | NE |
Standings
| AFC East | Overall W-L-T | Division W-L-T | |
 | New England | 12-4-0 | 5-1-0 |
 | Buffalo | 10-6-0 | 3-3-0 |
 | New York | 7-9-0 | 2-4-0 |
 | Miami | 5-11-0 | 2-4-0 |