Indianapolis Colts
| Team Ranking | Overall | Rushing | Passing |
| Offense | 25th | 133.1 (7th) | 194.2 (30th) |
| Defense | 16th | 97.9 (7th) | 248.9 (23rd) |
Schedule
* Sat Aug 13 4:00 pm ET | NFLN | @BUF |
* Sat Aug 20 1:00 pm ET | DET | |
* Sat Aug 27 7:30 pm ET | TB | |
| Sun Sep 11 1:00 pm ET | CBS | @HOU |
| Sun Sep 18 1:00 pm ET | CBS | @JAC |
| Sun Sep 25 1:00 pm ET | CBS | KC |
| Sun Oct 2 1:00 pm ET | FOX | TEN |
| Thu Oct 6 8:15 pm ET | AMZN | @DEN |
| Sun Oct 16 1:00 pm ET | CBS | JAC |
| Sun Oct 23 1:00 pm ET | CBS | @TEN |
| Sun Oct 30 4:25 pm ET | FOX | WAS |
| Sun Nov 6 1:00 pm ET | CBS | @NE |
| Sun Nov 13 4:05 pm ET | CBS | @LV |
| Sun Nov 20 1:00 pm ET | CBS | PHI |
| Mon Nov 28 8:15 pm ET | ESPN | PIT |
| Sun Dec 4 8:20 pm ET | NBC | @DAL |
| Sun Dec 18 TBA | @MIN | |
| Mon Dec 26 8:15 pm ET | ESPN | LAC |
| Sun Jan 1 1:00 pm ET | CBS | @NYG |
| Sun Jan 8 TBA | HOU |
Standings
| AFC South | Overall W-L-T | Division W-L-T | |
 | Houston | 10-6-0 | 4-2-0 |
 | Tennessee | 9-7-0 | 3-3-0 |
 | Indianapolis | 7-9-0 | 3-3-0 |
 | Jacksonville | 6-10-0 | 2-4-0 |