| Transactions |
| Date | Player | POS | Transaction |
|---|
| June 17, 2022 | Mathew Sexton | WR | on IR, undisclosed |
| June 16, 2022 | Aaron Parker | WR | signed |
| June 16, 2022 | Chris Lammons | DB | re-signed/unrest FA |
| June 16, 2022 | Luq Barcoo | CB | cut |
| June 14, 2022 | Darryl Williams | C | cut |
| June 13, 2022 | Jerick McKinnon | RB | re-signed, One-year contract (through 2022) |
| June 13, 2022 | Skyy Moore | WR | signed/draft choice, Four-year contract (through 2025) |
| June 9, 2022 | Joshua Williams | CB | signed/draft choice, Four-year contract (through 2025) |
| June 1, 2022 | Leo Chenal | LB | signed/draft choice, Four-year contract (through 2025) |
| May 31, 2022 | Jody Fortson | TE | re-signed/excl. FA, One-year contract (through 2022) |
| May 16, 2022 | Vitaliy Gurman | OT | signed |
| May 10, 2022 | Anthony Gordon | QB | cut |
| May 10, 2022 | Austin Reiter | C | signed |
| May 10, 2022 | Brenden Knox | RB | cut |
| May 10, 2022 | Chris Glaser | OG | signed |
| May 10, 2022 | Darius Stills | DT | cut |
| May 10, 2022 | Gary Jennings | WR | signed |
| May 10, 2022 | Gene Pryor | OT | cut |
| May 9, 2022 | Bryan Cook | SAF | signed/draft choice, Four-year contract (through 2025) |
| May 9, 2022 | Darian Kinnard | OG | signed/draft choice, Four-year contract (through 2025) |
| May 9, 2022 | Dustin Crum | QB | signed |
| May 9, 2022 | Gene Pryor | OT | signed |
| May 9, 2022 | George Karlaftis | DE | signed/draft choice, Four-year contract (fifth-year option) |
| May 9, 2022 | Isaih Pacheco | RB | signed/draft choice, Four-year contract (through 2025) |
| May 9, 2022 | Jack Cochrane | LB | signed |
| May 9, 2022 | Jaylen Watson | CB | signed/draft choice, Four-year contract (through 2025) |
| May 9, 2022 | Jerrion Ealy | RB | signed |
| May 9, 2022 | Justyn Ross | WR | signed |
| May 9, 2022 | Mike Caliendo | OG | signed |
| May 9, 2022 | Mike Rose | LB | signed |
| May 9, 2022 | Nasir Greer | DB | signed |
| May 9, 2022 | Nazeeh Johnson | CB | signed/draft choice, Four-year contract (through 2025) |
| May 9, 2022 | Tayon Fleet-Davis | RB | signed |
| May 9, 2022 | Trent McDuffie | CB | signed/draft choice, Four-year contract (fifth-year option) |
| May 6, 2022 | Austin Reiter | C | cut |
| May 6, 2022 | Lorenzo Neal | DT | cut |
| May 5, 2022 | Gary Jennings | WR | cut |
| May 5, 2022 | Gehrig Dieter | WR | cut |
| May 5, 2022 | Jonathan Woodard | DE | cut |
| May 5, 2022 | Josh Pederson | TE | cut |
| May 5, 2022 | Nakia Griffin-Stewart | | cut |
| May 3, 2022 | Chris Finke | WR | cut |
| May 2, 2022 | Lonnie Johnson | CB | traded, for 2024 seventh-round draft pick |
| Apr 27, 2022 | Anthony Gordon | QB | signed, One-year contract (through 2022) |
| Apr 7, 2022 | Derrick Gore | RB | re-signed/excl. FA, One-year contract (through 2022) |
| Apr 5, 2022 | Taylor Stallworth | DT | signed/unrest FA, One-year contract (through 2022) |
| Mar 28, 2022 | Deon Bush | DB | signed/unrest FA, One-year contract (through 2022) |
| Mar 27, 2022 | Ronald Jones | RB | signed/unrest FA, One-year contract (through 2022) |
| Mar 25, 2022 | Jermaine Carter | LB | signed/unrest FA, One-year contract (through 2022) |
| Mar 24, 2022 | Austin Reiter | C | signed, One-year contract (through 2022) |
| Mar 24, 2022 | Blake Bell | TE | re-signed/unrest FA, One-year contract (through 2022) |
| Mar 24, 2022 | Corey Coleman | WR | signed, One-year contract (through 2022) |
| Mar 24, 2022 | Geron Christian | OT | signed/unrest FA, One-year contract (through 2022) |
| Mar 24, 2022 | Luq Barcoo | CB | signed, One-year contract (through 2022) |
| Mar 24, 2022 | Marquez Valdes-Scantling | WR | signed/unrest FA, Three-year contract (through 2024) |
| Mar 23, 2022 | Elijah Lee | OLB | signed/unrest FA, One-year contract (through 2022) |
| Mar 22, 2022 | Derrick Nnadi | NT | re-signed/unrest FA, One-year contract (through 2022) |
| Mar 21, 2022 | JuJu Smith-Schuster | WR | signed/unrest FA, One-year contract (through 2022) |
| Mar 21, 2022 | Michael Burton | FB | re-signed/unrest FA, One-year contract (through 2022) |
| Mar 17, 2022 | Andrew Wylie | OG | re-signed/unrest FA, One-year contract (through 2022) |
| Mar 17, 2022 | Justin Reid | SS | signed/unrest FA, Three-year contract (through 2024) |
| Mar 16, 2022 | Alex Okafor | DE | Declared Free Agent |
| Mar 16, 2022 | Andrew Wylie | OG | Declared Free Agent |
| Mar 16, 2022 | Armani Watts | DB | Declared Free Agent |
| Mar 16, 2022 | Austin Blythe | C | Declared Free Agent |
| Mar 16, 2022 | Ben Niemann | LB | Declared Free Agent |
| Mar 16, 2022 | Blake Bell | TE | Declared Free Agent |
| Mar 16, 2022 | Byron Pringle | WR | Declared Free Agent |
| Mar 16, 2022 | Chad Henne | QB | re-signed, One-year contract (through 2022) |
| Mar 16, 2022 | Charvarius Ward | CB | Declared Free Agent |
| Mar 16, 2022 | Chris Lammons | DB | Declared Free Agent |
| Mar 16, 2022 | Daniel Sorensen | DB | Declared Free Agent |
| Mar 16, 2022 | Darrel Williams | RB | Declared Free Agent |
| Mar 16, 2022 | Demarcus Robinson | WR | Declared Free Agent |
| Mar 16, 2022 | Derrick Nnadi | NT | Declared Free Agent |
| Mar 16, 2022 | Dorian O'Daniel | LB | Declared Free Agent |
| Mar 16, 2022 | Jarran Reed | DT | Declared Free Agent |
| Mar 16, 2022 | Jerick McKinnon | RB | Declared Free Agent |
| Mar 16, 2022 | Kyle Long | OG | Declared Free Agent |
| Mar 16, 2022 | Marcus Kemp | WR | Declared Free Agent |
| Mar 16, 2022 | Melvin Ingram | LB | Declared Free Agent |
| Mar 16, 2022 | Michael Burton | FB | Declared Free Agent |
| Mar 16, 2022 | Mike Hughes | CB | Declared Free Agent |
| Mar 16, 2022 | Mike Remmers | OG | Declared Free Agent |
| Mar 16, 2022 | Tyrann Mathieu | FS | Declared Free Agent |
| Mar 8, 2022 | Orlando Brown | OT | Designated franchise player, non-exclusive franchise tag |
| Feb 22, 2022 | Anthony Hitchens | MLB | cut |
| Feb 22, 2022 | Brandin Dandridge | DB | signed |
| Feb 15, 2022 | Malik Herring | DE | reinstated |
| Feb 11, 2022 | Josh Pederson | TE | signed |
| Feb 9, 2022 | Shilique Calhoun | LB | signed |
| Feb 7, 2022 | Andrew Billings | DT | pract. squad del |
| Feb 7, 2022 | Joe Jackson | DE | pract. squad del |
| Feb 7, 2022 | Jonathan Woodard | DE | signed |
| Feb 7, 2022 | Nakia Griffin-Stewart | | signed |
| Feb 5, 2022 | Justin Watson | WR | signed |
| Feb 2, 2022 | Austin Edwards | DE | signed |
| Feb 2, 2022 | Cornell Powell | WR | signed |
| Feb 2, 2022 | Cortez Broughton | DT | signed |
| Feb 2, 2022 | Darius Harris | LB | signed |
| Feb 2, 2022 | Darryl Williams | C | signed |
| Feb 2, 2022 | Daurice Fountain | WR | signed |
| Feb 2, 2022 | Devon Key | SAF | signed |
| Feb 2, 2022 | Dicaprio Bootle | CB | signed |
| Feb 2, 2022 | Gehrig Dieter | WR | signed |
| Feb 2, 2022 | Josh Gordon | WR | signed |
| Feb 2, 2022 | Mark Vital | TE | signed |
| Feb 2, 2022 | Matt Bushman | TE | signed |
| Feb 2, 2022 | Roderick Johnson | OT | signed |
| Jan 31, 2022 | Daurice Fountain | WR | pract. squad add |
| Jan 29, 2022 | Daurice Fountain | WR | active/prac. squad |
| Jan 26, 2022 | Josh Gordon | WR | pract. squad add |
| Jan 24, 2022 | Daurice Fountain | WR | pract. squad add |
| Jan 24, 2022 | Josh Gordon | WR | cut |
| Jan 22, 2022 | Daurice Fountain | WR | active/prac. squad |
| Jan 20, 2022 | Joe Jackson | DE | pract. squad add |
| Jan 19, 2022 | Andrew Billings | DT | pract. squad add |
| Jan 19, 2022 | Chris Finke | WR | signed |
| Jan 19, 2022 | Elijah McGuire | RB | pract. squad del |
| Jan 19, 2022 | Mark Vital | TE | pract. squad add |
| Jan 19, 2022 | Roderick Johnson | OT | pract. squad add |
| Jan 18, 2022 | Elijah Sullivan | LB | pract. squad del |
| Jan 18, 2022 | Josh Jackson | CB | pract. squad del |
| Jan 18, 2022 | Nakia Griffin-Stewart | | pract. squad del |
| Jan 18, 2022 | Shilique Calhoun | LB | pract. squad del |
| Jan 17, 2022 | Daurice Fountain | WR | pract. squad add |
| Jan 15, 2022 | Daurice Fountain | WR | active/prac. squad |
| Jan 14, 2022 | Josh Jackson | CB | pract. squad add |
| Jan 12, 2022 | Mark Vital | TE | pract. squad del, COVID-19 |
| Jan 11, 2022 | Brenden Knox | RB | signed |
| Jan 11, 2022 | Darius Stills | DT | signed |
| Jan 11, 2022 | Gary Jennings | WR | signed |
| Jan 11, 2022 | Jordan Franks | TE | signed |
| Jan 11, 2022 | Lorenzo Neal | DT | signed |
| Jan 11, 2022 | Mathew Sexton | WR | signed |
| Jan 11, 2022 | Omar Bayless | WR | signed |
| Jan 7, 2022 | Lucas Niang | OT | on IR, knee |
| Jan 5, 2022 | Josh Jackson | CB | pract. squad del, COVID-19 |
| Jan 5, 2022 | Matt Bushman | TE | pract. squad add |
| Jan 4, 2022 | Khalen Saunders | DT | reserve/non football injury, COVID-19 |
| Jan 3, 2022 | Mike Remmers | OG | reinstated |
| Dec 29, 2021 | Armani Watts | DB | reinstated |
| Dec 29, 2021 | Darius Harris | LB | pract. squad add |
| Dec 29, 2021 | Harrison Butker | K | reinstated |
| Dec 29, 2021 | Rashad Fenton | DB | reinstated |
| Dec 29, 2021 | Tommy Townsend | P | reinstated |
| Dec 28, 2021 | Dalton Schoen | WR | pract. squad del |
| Dec 28, 2021 | Daurice Fountain | WR | pract. squad add |
| Dec 28, 2021 | Elliott Fry | K | cut |
| Dec 28, 2021 | Johnny Townsend | P | pract. squad del |
| Dec 28, 2021 | Paul Adams | OT | pract. squad del |
| Dec 27, 2021 | Dicaprio Bootle | CB | pract. squad add |
| Dec 27, 2021 | Gehrig Dieter | WR | pract. squad add |
| Dec 27, 2021 | Johnny Townsend | P | pract. squad add |
| Dec 27, 2021 | Joseph Charlton | P | pract. squad del |
| Dec 27, 2021 | Josh Jackson | CB | pract. squad add |
| Dec 27, 2021 | Kyle Long | OG | reinstated |
| Dec 27, 2021 | Nakia Griffin-Stewart | | pract. squad add |
