Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. AllenJosh Allen | K. AllenKyle Allen | — |
| Running Back | J. CookJames Cook | L. MurrayLatavius Murray | |
| Fullback | R. GilliamReggie Gilliam | — | — |
| Wide Receiver | S. DiggsStefon Diggs | G. DavisGabe Davis | |
| Tight End | D. KnoxDawson Knox | D. KincaidDalton Kincaid | |
| Left Tackle | D. DawkinsDion Dawkins | R. Van DemarkRyan Van Demark | — |
| Left Guard | C. McGovernConnor McGovern | D. EdwardsDavid Edwards | — |
| Center | M. MorseMitch Morse | R. BatesRyan Bates | — |
| Right Guard | O. TorrenceO'Cyrus Torrence | A. AndersonAlec Anderson | — |
| Right Tackle | S. BrownSpencer Brown | G. IfediGermain Ifedi | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | G. RousseauGreg Rousseau | A. EpenesaA.J. Epenesa | |
| Right Defensive End | L. FloydLeonard Floyd | S. LawsonShaq Lawson | |
| Left Defensive Tackle | E. OliverEd Oliver | J. PhillipsJordan Phillips | |
| Right Defensive Tackle | D. JonesDaQuan Jones | T. SettleTim Settle | — |
| Strongside Linebacker | M. MilanoMatt Milano | T. MatakevichTyler Matakevich | — |
| Middle Linebacker | T. BernardTerrel Bernard | T. DodsonTyrel Dodson | |
| Weakside Linebacker | D. WilliamsDorian Williams | T. MatakevichTyler Matakevich | — |
| Right Cornerback | C. BenfordChristian Benford | D. JacksonDane Jackson | |
| Left Cornerback | T. WhiteTre'Davious White | T. JohnsonTaron Johnson | |
| Strong Safety | J. PoyerJordan Poyer | T. RappTaylor Rapp | — |
| Free Safety | M. HydeMicah Hyde | D. HamlinDamar Hamlin | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | S. MartinSam Martin | — | — |
| Kicker | T. BassTyler Bass | — | — |
| Long Snapper | R. FergusonReid Ferguson | — | — |
| Holder | S. MartinSam Martin | — | — |
| Punt Returner | D. HartyDeonte Harty | K. ShakirKhalil Shakir | |
| Kick Returner | D. HartyDeonte Harty | K. ShakirKhalil Shakir |